The expression of transgenes encoding insecticidal proteins from Bacillus thuringiensis (Bt) is a well-established technology that enhances protection against lepidopteran larvae (butterflies and moths), which affect crop production worldwide. However, resistance is emerging, creating an urgent need for new agents. We have discovered a new protein family from ferns (Pteris species), which has strong activity against pests of maize and soybean. The crystal structure of a family variant reveals that despite being derived from plants, these proteins resemble two of the three domains from the structures of Bt bacterial insecticidal proteins. The proteins from ferns control insect resistant to Bt insecticidal proteins, indicating different modes and/or sites of action and therefore provide a potential new avenue for the control of insect pests.
This presentation will describe our recent characterisation of these IPD113 or fern insecticidal proteins (Fips), their structures and possible modes of action.